LETTER TO EDITOR
Year: 2020 • Volume: 3 • Issue: 3 • Page: 74-75
TOPICAL STEROID ABUSE CAUSING GIANT AND DISSEMINATED MOLLUSCUM CONTAGIOSUM
Tapaswini Tripathy1, Manish K Sahu1, Bhabani STP Singh1, Bikash R Kar1
1Department of Dermatology, IMS & SUM Hospital
Corresponding Author:
Dr Tapaswini Tripathy
Department of Skin & VD, IMS & SUM Hospital, Bhubaneswar
Mob- 8895226924
How to cite this article:
Tripathy T, Sahu MK, Singh BSTP, Kar BK. Topical steroid abuse causing giant and disseminated molluscum contagiosum. JDA Indian Journal of Clinical Dermatology. 2020;3:74-75
Sir,
Molluscum contagiosum is an infectious dermatosis caused by molluscum contagiosum virus of poxviridae family. Primarily young children, sexually active individuals and immunosuppressed persons are affected by this disease. It tends to be benign and self-limited in children and immunocompetent individuals. Atypical presentations like giant morphology and disseminated distribution are markers of immunodeficiency.[1]
A seventy-nine-year-old female presented to our dermatology outpatient department with multiple asymptomatic papules and nodules over face, trunk, and extremities. Lesions appeared gradually over a period of 6 months. Few of them increased in size. Patient was applying halobetasol propionate ointment all over body for generalized pruritus for the past 5-6 years without any medical advice. There was no history of loss of appetite, weight loss or any symptoms pertaining to immune suppression. General and systemic examination did not reveal any abnormality. Oncutaneousexamination, there were multiple skin coloured to pearly white dome-shaped papules and nodules of variable sizes with central umbilication over face, neck,chest, upper extremities and retroauriculararea (Figure 1a).Thelargest nodule measured around 2cm in diameter. Background skin of affected area showed generalized erythema, telangiectasia, thinning and ecchymotic patches suggestive of topical steroid abuse (Figure 1b, Figure 1c). Mucosae, hair and nails were normal. Fig 1a,b,c
Fig 2,3Dermoscopy of the nodular lesion showed central whitish to yellow homogenous areas with surrounding telangiectasia (Figure 2). Routine haematological tests, liver function tests and renal function testswere within normal limits. Enzyme-linked immunosorbentassay for HIV was negative. Early morning serum cortisol was 17μg/dL. X-ray chest and spine and ultrasonography of abdomen and pelvis did not reveal any abnormality. Histopathology of the nodule revealed nests of s q u a m o u s c e l l s c o n t a i n i n g e o s i n o p h i l i c intracytoplasmicinclusion bodies (Figure 3). Based on clinical features, dermoscopy and histological findings a diagnosis of disseminated and giant molluscum contagiosum was made. Patient was advised to stop halobetasol. Larger troublesome lesions were treated with cryotherapy. Smaller lesions were treated with chemical cauterisation with phenol.
Disseminated and giant molluscum contagiosum has been reported in conditions of impaired cell-mediated immunity like HIV disease, haematological malignancy, idiopathic CD4 lymphocytopenia, sarcoidosis, hyper IgE syndrome.1There are reports of disseminated molluscum contagiosum in patients on methotrexate and other immunosuppressive therapy.2 Children on treatment with topical calcineurin inhibitors have also developed disseminated molluscum during therapy.3
In the past few years, there has been increased and inappropriate use of topical steroids without any medical advice. It is mainly due to potent anti-inflammatory actions of steroids that renders rapid symptomatic relief in many dermatoses. Several over the counter preparations containing steroids are often misused as fairness and anti-acne creams, resulting in alarming side effects. The topical steroid-induced adverse events are also on the rise.
Cell-mediated immunity plays an important role in protecting the host from viral infection. Cytotoxic T lymphocytes, natural killer cells (NK cells), anti-viral macrophages and cytokines like interferon gamma (IFN-γ) and tumour necrosis factor alpha (TNF-α) play a major role in first-line defence against viral infection. Besides inhibiting cells of innate immunity glucocorticoids inhibit expression of many cytokines like IFN-γ and TNF-α. Prolong use of topical steroid renders an individual immunosuppressed making him susceptible to infections and the risk is,even more, when potent steroids are used.4 The index case was applying high potency topical steroid all over body for a prolonged period that resulted in immunosuppression and consequently disseminated and giant molluscum contagiosum. On the literature search, we found only single case report of molluscum contagiosum following topical steroid use in 1971 by Hellier FF.5
As topical steroids are the most frequently used medication in dermatologic practice, its abuse is of matter of concern. Thorough patient education and appropriate use can prevent potentially harmful untoward side effects.
Figure 1a: Dome-shaped papules and nodules of variable sizes with central umbilication over face, neck,chest with back ground erythema and telangiectasia
Figure 1b: Generalized erythema, telangiectasia, thinning and ecchymotic patches suggestive of topical steroid abuse.
Figure 1c: erythema, telangiectasia, thinning and ecchymotic patches suggestive of topical steroid abuse.
Figure 2: Dermoscopy of nodular lesion showing central whitish to yellow homogenous areas with surrounding telangiectasia (DL 3, contact polarized mode without interface fluid, x10).
Figure 3a: Nests of squamous cells containing eosinophilic intracytoplasmicinclusion bodies (H & E, 10X).
Figure 3b: Large eosinophilic intracytoplasmicinclusion bodies (H & E, 40X).
References
- Pérez-Díaz CE, Botero-García CA, Rodríguez MC, Faccini-Martínez ÁA, Calixto OJ, Benítez F et Giant molluscum contagiosum in an HIV positive patient. Int J Infect Dis2015;38:153-5.
- Bansal S, Relhan V, Roy E, Garg VK, Khurana N. Disseminated molluscum contagiosum in a patient on methotrexate therapy for psoriasis. Indian J Dermatol VenereolLeprol2014;80:179-80.
- Goksugur N, Ozbostanci B, Goksugur SB. Molluscum contagiosum infection associated with pimecrolimus use in pityriasis alba. Pediatr Dermatol 2007;24:E63-5.
- Kannan S, Khan W, Bharadwarj A, Rathore BS, Khosla Corticosteroid-induced cutaneous changes: a cross-sectional study. Indian J Pharmacol2015;47:696-8.
- Hellier FF. Profuse molluscacontagiosa of the face induced by corticosteroids. Br J Dermatol 1971;85:398.
Nice idea
dfgdlfg2131.32
https://howyoutoknowa.online/map.php
sumatriptan sale – sumatriptan order online cost sumatriptan 50mg
Психолог онлайн. Консультация Психолога онлайн – 5872 врачей, 7098 отзывов.
сваты 5 17 серия
просмотреть фильм онлайн бесплатно
Site
разные фильмы
онлайн смотреть бесплатно в хорошем качестве
site
site
бій джошуа та вусика
бэтмен кристиан бейл
883
2367
site
134
Где
https://drugsoverthecounter.com/# cvs over the counter covid test
1595
Carter, USA 2022 05 05 05 34 19 where can i buy stromectol ivermectin online PMID 30206202 Free PMC article
generic propecia online 068 Fatty liver present absent 0
haloperidol increases toxicity of buprenorphine, long acting injection by pharmacodynamic synergism how to buy priligy as a child They will provide invaluable streams of resources that will serve you for many decades
The dual mTOR inhibitor AZD2014, when combined with the hormonal therapy fulvestrant Faslodex, was found to be safe in patients with advanced estrogen receptor positive breast cancer, and some of them experienced clinical benefit from the drug combination, according to phase I clinical dutasteride vs finasteride 2014 For years he has been testifying in court and in the media that persistent Lyme doesn t exist and that Lyme disease is no big deal its not like its HIV when that is exactly what it is like when Lyme has impacted your immune system so greatly that you have immune, autoimmune, and neuroimmune disease due to Lyme Disease
Mya olUXpAhryEwZM 5 20 2022 buy cialis 20mg
purchase arimidex for sale order arimidex 1mg pills arimidex ca
I agree with your point of view, your article has given me a lot of help and benefited me a lot. Thanks. Hope you continue to write such excellent articles.
Reading your article helped me a lot and I agree with you. But I still have some doubts, can you clarify for me? I’ll keep an eye out for your answers.
художественные фильмы бесплатно
ичиносе класс превосходство
Looking forward to reading more. great article. Really looking forward to reading more books. cool. I really enjoy reading a thought provoking article. Also, thanks for allowing me to comment!
I agree with your point of view, your article has given me a lot of help and benefited me a lot. Thanks. Hope you continue to write such excellent articles.
Don t forget the father is generic cialis available Articles were excluded as a result of anticancer therapy not given or reported or using a method to measure stiffness that was not PWV, AoD, or ОІ stiffness index
психолог
Your article gave me a lot of inspiration, I hope you can explain your point of view in more detail, because I have some doubts, thank you.